Table 1 Comparison of preoperative baseline characteristics in training cohort and the validation cohort
From: Abnormal coagulation after hepatectomy in patients with normal preoperative coagulation function
Parameters | All (n = 661) | Training cohort(n = 465) | Validation cohort(n = 196) | P |
|---|---|---|---|---|
General characteristics | ||||
PAC (%) | 0.766 | |||
Yes | 362 (54.8) | 253 (54.4) | 109 (55.6) | |
No | 299 (45.2) | 212 (45.6) | 87 (44.4) | |
Age, y | 55.06 ± 11.38 | 55.13 ± 11.48 | 54.88 ± 11.16 | 0.800 |
Gender, (%) | 0.599 | |||
Male | 554 (83.8) | 392 (84.3) | 162 (82.7) | |
Female | 107 (16.2) | 73 (15.7) | 34 (17.3) | |
BMI,, Kg/m2 | 23.16 ± 3.19 | 22.84 ± 3.20 | 22.96 ± 3.14 | 0.256 |
ASA grade, (%) | 0.717 | |||
1 | 29 (4.4) | 19 (4.1) | 10 (5.1) | |
2 | 505 (76.4) | 359 (77.2) | 146 (74.5) | |
3 | 127 (19.2) | 87 (18.7) | 40 (20.4) | |
MELD score | 17.34 ± 1.82 | 17.32 ± 1.76 | 17.38 ± 1.95 | 0.686 |
ALBI score | -2.57 ± 0.31 | -2.57 ± 0.31 | -2.59 ± 0.30 | 0.430 |
APRI score | 0.61 ± 0.61 | 0.60 ± 0.59 | 0.64 ± 0.66 | 0.465 |
FIB-4 score | 2.22 ± 1.90 | 2.23 ± 2.09 | 2.19 ± 1.37 | 0.804 |
Tumor diameter, cm | 6.06 ± 4.02 | 6.05 ± 4.29 | 6.08 ± 3.29 | 0.922 |
Preoperative complications | ||||
HBV infection, n (%) | 0.099 | |||
Yes | 515(77.9) | 368(79.1) | 147(75.0) | |
No | 146(22.1) | 97(20.9) | 49(25.0) | |
HP, n (%) | 0.899 | |||
Yes | 103 (15.6) | 73 (15.7) | 30 (15.3) | |
No | 558 (84.4) | 392 (84.3) | 166 (84.7) | |
CAD, No. (%) | 0.384 | |||
Yes | 18 (2.7) | 11 (2.4) | 7 (3.6) | |
No | 643 (97.3) | 454 (97.6) | 189 (96.4) | |
Diabetes, n (%) | 0.532 | |||
Yes | 54 ( 8.2) | 40 (8.6) | 14 (7.1) | |
No | 607 (91.8) | 425 (91.4) | 182 (92.9) | |
HL, n (%) | 0.655 | |||
Yes | 59 (8.9) | 43 (9.2) | 16 (8.2) | |
No | 602 (91.1) | 422 (90.8) | 180 (91.8) | |
COPD, No. (%) | 0.484 | |||
Yes | 18 (2.7) | 14 (3.0) | 4 (2.0) | |
No | 643 (97.3) | 451 (97.0) | 192 (98.0) | |
Liver cirrhosis, n (%) | 0.656 | |||
Yes | 181 (27.4) | 125 (26.9) | 56 (28.6) | |
No | 480 (72.6) | 340 (73.1) | 140 (71.4) | |
Laboratory measurements | ||||
Hb, g/L | 141.25 ± 17.75 | 141.04 ± 17.74 | 141.76 ± 17.80 | 0.634 |
PLT,×109/L | 189.67 ± 58.97 | 189.98 ± 59.92 | 188.72 ± 56.80 | 0.803 |
ALB, g/L | 39.34 ± 3.67 | 39.23 ± 3.62 | 39.60 ± 3.77 | 0.245 |
TBIL,µmol/L | 16.92 ± 15.00 | 16.64 ± 14.97 | 17.56 ± 15.07 | 0.245 |
UREA,µmol/L | 4.99 ± 1.66 | 5.04 ± 1.79 | 4.87 ± 1.31 | 0.225 |
CREA,µmol/L | 78.55 ± 33.29 | 79.58 ± 38.52 | 76.13 ± 14.59 | 0.224 |
ALT, U/L | 30.0 (20.0, 44.0) | 30.0(19.0,46.3) | 30.0(20.0,44.0) | 0.573 |
AST, U/L | 32.0 (24.0, 45.0) | 34.0(25.0,48.0) | 32.0(24.0,44.0) | 0.349 |
GGT, U/L | 54.0 (32.0, 105.0) | 56.0(34.0,108.5) | 54.0(31.0,104.0) | 0.528 |
LDH, U/L | 200.0 (172.0, 233.0) | 199.0(172.0,236.3) | 200.0(172.0,231.0) | 0.848 |
ALP, U/L | 82.0 (69.0, 104.0) | 83.5(70.0,105.8) | 80.0(68.0,103.0) | 0.176 |
CHE, U/L | 6711 ± 1552 | 6738 ± 1646 | 6648 ± 1306 | 0.496 |
PT, s | 11.89 ± 0.55 | 11.89 ± 0.54 | 11.87 ± 0.58 | 0.633 |
PT% | 93.46 ± 8.09 | 93.30 ± 7.86 | 93.82 ± 8.63 | 0.452 |
INR | 1.02 ± 0.05 | 1.02 ± 0.05 | 1.01 ± 0.05 | 0.152 |
APTT, s | 28.01 ± 1.86 | 27.95 ± 1.74 | 28.15 ± 2.12 | 0.218 |
TT, s | 18.44 ± 1.17 | 18.46 ± 1.19 | 18.42 ± 1.14 | 0.706 |
FIB, g/L | 2.65 ± 1.17 | 2.67 ± 0.47 | 2.60 ± 0.46 | 0.093 |
Preoperative medication | ||||
ACEI/ARB, n (%) | 0.600 | |||
Yes | 13 (2.0) | 10 (2.2) | 3 (1.5) | |
No | 648 (98.0) | 455 (97.8) | 193 (98.5) | |
CCB, n (%) | 0.627 | |||
Yes | 77 (11.6) | 56 (12.0) | 21 (10.7) | |
No | 584 (88.4) | 409 (88.0) | 175 (89.3) | |
Preoperative Nsaids, n(%) | 0.272 | |||
Yes | 17 (2.6) | 14 (3.0) | 3 (1.5) | |
No | 644 (97.4) | 451 (97.0) | 193 (98.5) | |
Statin (%) | 0.328 | |||
Yes | 9 (1.4) | 5 (1.1) | 4 (2.0) | |
No | 652 (98.6) | 460 (98.9) | 192 (98.0) | |
Diuretics, n (%) | 192 (98.0) | 454 (97.6) | 0.798 | |
Yes | 15 (2.3) | 4 (2.0) | 11 (2.4) | |
No | 646 (97.7) | 1354 (95.6) | 581 (96.2) | |
Hormones, n (%) | 0.109 | |||
Yes | 7 (1.1) | 3 (0.6) | 4 (2.0) | |
No | 654 (98.9) | 462 (99.4) | 192 (98.0) |