Risk factors, impact and treatment of postoperative lymphatic leakage in children with abdominal neuroblastoma operated on by laparotomy

Table 3 Impact of lymphatic leakage on children with NB

Characteristics		lymphatic leakage^1,2	Non-lymphatic leakage	Results³	p Value
Characteristics		(n = 32)	(n = 154)	Results³	p Value
Maximum abdominal drainage (ml/day)		405 (218.8, 542.5)	90 (40, 160)	6.937	< 0.001
Average abdominal drainage (ml/day)		138.4 (94.3, 211)	39.7 (25, 69.2)	6.841	< 0.001
Abdominal drainage time (days)		15 (10, 23)	8 (7, 10)	7.171	< 0.001
Complications related to lymphatic leakage		17 (53.1)	0	52.316	< 0.001
Hospitalization (days)		18 (13, 27)	11 (9, 13)	5.631	< 0.001
Time from operation to chemotherapy (days)⁴		23 (17, 30)	15 (13, 17)	-3.166	0.002
	> 3 weeks	17 (53.1)	18 (17.6)		< 0.0001
	< 3 weeks	15 (46.9)	84 (82.4)
Three-year	OS	77.4% (95% CI: 64.0–93.6%)	85.5% (95% CI: 80.1–91.3%)		0.21
	EFS	58.6% (95% CI: 43.2–79.6%)	75.1% (95% CI: 68.5–82.4%)		0.057
	CILP	16.7% (95% CI: 2.3–29.0%)	4.9% (95% CI: 1.3–8.4%)		0.015

¹Continuous variables are presented as the median and interquartile range.
²Classification variables are presented as numbers (percent).
³Results represent the z value of the Mann-Whitney test and the χ2 value of the chi-square test, respectively.
⁴Postoperative chemotherapy was performed in 32 cases in lymphatic leakage group and 102 cases in non-lymphatic leakage group.

ISSN: 1471-2482