Effect of mild hypothermia vs normothermia cardiopulmonary bypass on postoperative bleeding in patients undergoing coronary artery bypass grafting: protocol of a multi-center, randomized, controlled trial

Table 1 Assessment schedule

Assessment	STUDY PERIOD
	Visit 1	Visit 2	Visit 3	Visit 4	Visit 5
	Baseline 7 days to 0 days	CPB initiation	Rewarming	Within 48 h after surgery	Surgery to discharge
Informed consent	√
Inclusion/exclusion criteria	√
Randomization	√
Basic medical history	√
Blood laboratory test	√	√	√	√	√
Blood gas analysis	√	√	√	√	√
Coagulation function		√	√	√
Coagulation factors		√	√
Inflammatory factors		√	√
Chest tube output				√	√
Blood product transfusion		√	√	√	√
UDPB				√
AE, SAE, and endpoints		√	√	√	√

AE, adverse events; CPB, cardiopulmonary bypass; SAE, severe adverse events; UDPB, Universal Definition of Perioperative Bleeding

ISSN: 1471-2482