Skip to main content

Table 2 Pooled effect size and heterogeneity tests outcomes including IBL, TBL, postoperative drainage, postoperative hematological variables, postoperative blood transfusions, and complication using the random-effects model

From: Efficacy and safety of topical versus intravenous tranexamic acid in spinal surgery: a systematic review and meta-analysis

Outcome

Study type

No. of studies

Effect size (95% CI)

I2 (%)

p-Heterogeneity

p-value

IBL

RCT

5

1.16 (0.38, 1.94)

93

< 0.0001

0.004

 

non-RCT

1

-0.26 (-0.78, 0.27)

NA

NA

0.335

TBL

RCT

2

0.52 (0.05, 0.99)

72.1

0.058

0.03

 

non-RCT

1

-0.25 (-0.78, 0.27)

NA

NA

0.341

Postoperative drainage

RCT

3

0.54 (-0.06, 1.14)

81.6

0.004

0.077

 

non-RCT

1

-0.07 (-0.59, 0.45)

NA

NA

0.792

HB postoperative 1 day

RCT

1

-1.214 (-1.807, -0.621)

NA

NA

0

 

non-RCT

0

NA

NA

NA

NA

HB postoperative 3 days

RCT

2

-2.301 (-5.937, 1.334)

97.8

< 0.0001

0.215

 

non-RCT

0

NA

NA

NA

NA

HCT postoperative 1 day

RCT

1

-0.381 (-0.929, 0.168)

NA

NA

0.174

 

non-RCT

0

NA

NA

NA

NA

HCT postoperative 3 day

RCT

3

-0.766 (-1.443, -0.088)

84.7

0.001

0.027

 

non-RCT

0

NA

NA

NA

NA

Postoperative blood transfusions

RCT

4

0.892 (0.470, 1.693)

0

0.859

0.727

 

non-RCT

0

NA

NA

NA

NA

Complications

RCT

4

0.864 (0.309, 2.417)

0

0.492

0.781

 

non-RCT

0

NA

NA

NA

NA

  1. RCT, randomised controlled trial; NA, lack of sufficient number of studies; IBL, intraoperative blood loss; TBL, total blood loss; HB, hemoglobin; HCT, hematocrit