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Table 2 Summary of findings on the effects of PSUS on ultrasound evaluation outcomes and surgical parameters

From: Ultrasound outcomes and surgical parameters of the double-layer purse-string uterine closure technique in cesarean delivery: a systematic review and meta-analysis of randomized trials

Outcomes

Anticipated absolute effects [95% CI]

Relative effect [95% CI]

No of Participants [studies]

Quality of the evidence

Risk with control

Risk with PSUS

Postsurgical ultrasound measurements

Uterine scar defects

400 per 1000

180 per 1000 (144 to 232)

RR 0.45 (0.36 to 0.58)

751 [8 RCT]

Moderate

Length of the uterine incision (in millimeters)

The mean of length of the uterine incision in the control groups was 20.5

The mean of length of the uterine incision in the intervention group was − 3.84 lower (-4.97 to -2.71)

MD -3.84 (-4.97 to -2.71)

438 [4 RCT]

low

OO

Length of the incision defect (in millimeters)

The mean of length of the incision defect in the control groups was 6.35

The mean of length of the incision defect in the intervention group was − 1.91 lower (-4.42, 0.60)

MD -1.91 (-4.42 to 0.60)

432 [4 RCT]

Very Low

Height of the incision defect (in millimeters)

The mean of height of uterine incision defect in the control groups was 3.04

The mean of height of the incision defect in the intervention group was − 0.27 lower (-0.59 to 0.05)

MD -0.27 (-0.59 to 0.05)

438 [4 RCT]

Very Low

RMT (in millimeters)

The mean of RMT in ultrasound evaluation in the control groups was 6.18

The mean of postpartum perineal pain in the intervention group was 1.33 higher (0.72 to 1.94)

MD 1.33 (0.72 to 1.94)

417 [5 RCT]

Low

Surgical parameters

Duration of the operation (in minutes)

The mean of duration of the operation in the control groups was 32.9

The mean of operation time in the intervention group was 1.30 higher (-0.24 to 2.83)

MD 1.30 (-0.24 to 2.83)

491 [5 RCT]

Very Low

Amount of blood loss during the surgery (in milliliters)

The mean of postpartum perineal pain in the control groups was 498.1

The mean of postpartum perineal pain in the intervention group was 1.12 higher (-28.5 to 30.7)

MD 1.12 (-28.55 to 30.79)

171

Very Low

  1. Note: CI: confidence interval; MD: mean difference; RMT: residual myometrium thickness; RR: relative risk; PSUS: purse-string uterine suture
  2. GRADE Working Group grades of evidence
  3. Moderate quality: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
  4. Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
  5. Very low quality: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect
  6. The risk in the intervention group [and its 95% confidence interval] is based on the assumed risk in the comparison group and the relative effect of the intervention [and its 95% CI]
Patient or population: pregnant women with indications for cesarean section, gestational age over 34 weeks, and a singleton pregnancySetting: Tunisia; Egypt and TurkeyIntervention: PSUSComparison: double-layered uterine closure; single-layered uterine closure