Comparative outcomes of proximal femur intramedullary nailing vs. cemented bipolar hemiarthroplasty for treating intertrochanteric fractures in patients aged 75 and older: analysis of risk factors for postoperative all-cause mortality

Table 9 Sensitivity analysis on ALT, AST, and de Ritis ratio as categorical variables and postoperative mortality

Categorical variables^c	Death	Patients	Unadjusted		Multivariable adjusted
Categorical variables^c	n	N	HR (95% CI)	P	HR (95% CI)	p
ALT
Low (≤ 9 IU/L)	16	56	Reference		Reference
Middle (9-19IU/L)	39	134	0.82 (0.46, 1.49)	0.517^a	0.78 (0.43, 1.42)	0.415^b
High (≥ 19IU/L)	11	51	0.54 (0.25, 1.18)	0.123^a	0.50 (0.23, 1.11)	0.090^b
AST
Low (≤ 14 IU/L)	19	51	Reference		Reference
Middle (14–24 IU/L)	38	140	0.63 (0.37, 1.10)	0.105^a	0.50 (0.28, 0.90)	0.020^b
High (≥ 24 IU/L)	9	50	0.35 (0.16, 0.78)	0.010^a	0.30 (0.13, 0.68)	0.004^b
De Ritis ratio
Low (≤ 1.08 IU/L)	19	46	Reference		Reference
Middle (1.08-2.00IU/L)	34	142	0.54 (0.31, 0.95)	0.033^a	0.45 (0.25, 0.81)	0.008^b
High (≥ 2.00IU/L)	13	53	0.73 (0.36, 1.49)	0.394^a	0.61 (0.29, 1.28)	0.192^b

Notes: ^a unadjusted analysis; ^b multivariable adjusted analysis; categorical variables were categorized into low (≤20th percentile), medium (20th–80th percentile), and high (≥ 80th percentile) trichotomies on the basis of the 20th and 80th percentiles¹⁵
Abbreviations: HR, hazard ratio; CI, confidence interval; AST, aspartate aminotransferase; ALT, alanine aminotransferase

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