Table 3 COX regression analysis of unifactorial and multifactorial OS in CRC patients (n = 46)

Age(years)

(≥ 60/ < 60)

6.639 (3.132 -14.070)

< 0.001

5.015 (2.335–10.771)

< 0.001

BMI(kg/m²)

1.026 (0.989 -1.065)

0.189

Hospitalization (day)

(≥ 25.5/ < 25.5)

1.294 (0.998 -1.679)

0.052

Gender

(Male/Female)

0.871 (0.680–1.116)

0.276

Smoking

(Yes/No)

0.786 (0.559–1.105)

0.166

Alcohol

(Yes/No)

0.775 (0.513–1.169)

0.224

Diabetes

(Yes/No)

1.747 (1.234–2.472)

0.002

1.483 (1.021–2.156)

0.038

Hypertension

(Yes/No)

1.335 (1.035–1.721)

0.026

1.121 (0.834–1.508)

0.449

Cardiovascular disease

(Yes/No)

1.726 (1.209–2.462)

0.003

1.322 (0.894–1.955)

0.161

Abdominal operation

(Yes/No)

1.125 (0.848–1.493)

0.413

Intestinal polyps

(Yes/No)

2.039 (1.537–2.706)

< 0.001

2.639 (1.936–3.596)

< 0.001

Chemotherapy

(Yes/No)

0.084 (0.021–0.344)

0.001

0.598 (0.142–2.523)

0.484

Surgical options

(Yes/No)

0.424 (0.310–0.580)

< 0.001

0.484 (0.313–0.614)

< 0.001

Drainage tube

(Yes/No)

0.138 (0.093–0.204)

< 0.001

0.095 (0.062–0.147)

< 0.001

Tumor location

(Descending/ Sigmoid/ Rectum)

0.583 (0.458–0.741)

< 0.001

0.834 (0.623–1.037)

0.093

Tumor diameter

(≥ 5/ < 5)

1.210 (0.952–1.538)

0.120

Tumor differentiation

(Poor/ Medium/ High)

0.558 (0.179–1.742)

0.315

TNM Stage

(I/II/III/IV)

1.849 (0.862–9.015)

< 0.001

3.367 (2.341–9.971)

< 0.001

CEA(ng/mL)

1.004 (1.001–1.007)

0.011

1.001 (0.998–1.004)

0.540

Leukocyte (10⁹/L)

1.012 (0.971–1.055)

0.572

Neutrophil (10⁹/L)

1.047 (1.003–1.093)

0.038

1.044 (0.984–1.108)

0.155

Platelet (10⁹/L)

1.001 (0.999–1.003)

0.291

Lymphocyte (10⁹/L)

0.686 (0.557–0.846)

0.182

Hemoglobin (g/L)

0.994 (0.989–0.999)

0.024

0.998 (0.991–1.004)

0.467

Albumin (g/dL)

0.973 (0.945–1.002)

0.065

0.995 (0.967–1.024)

0.735

NLR(10⁹/L)

(≥ 2.61/ < 2.61)

1.676 (1.318–2.130)

< 0.001

1.071 (0.778–1.475)

0.006

PLR(10⁹/L)

(≥ 204.04/ < 204.04)

2.081 (1.592–2.719)

< 0.001

1.658 (1.192–2.307)

0.003