Table 4 COX regression analysis of unifactorial and multifactorial DFS in CRCpatients (n = 16)

Age(years)

(≥ 60/ < 60)

0.448 (0.296 -0.680)

0.000

0.521 (0.354–0.847)

0.003

BMI(kg/m²)

1.052 (1.006 -1.099)

0.027

1.061 (1.014–1.112)

0.015

Hospitalization (day)

(≥ 25.5/ < 25.5)

1.549 (1.146 -2.095)

0.004

1.524 (1.166–2.176)

0.008

Gender

(Male/Female)

0.916 (0.677 -1.239)

0.568

Smoking

(Yes/No)

1.214 (0.859–1.714)

0.272

Alcohol

(Yes/No)

1.210 (0.807–1.814)

0.356

Diabetes

(Yes/No)

1.074 (0.610–1.892)

0.804

Hypertension

(Yes/No)

0.930 (0.668–1.295)

0.667

Cardiovascular disease

(Yes/No)

0.828 (0.470–1.458)

0.513

Abdominal operation

(Yes/No)

0.998 (0.703–1.418)

0.993

Intestinal polyps

(Yes/No)

2.047 (1.416–2.959)

< 0.001

2.123 (1.593–3.476)

< 0.001

Chemotherapy

(Yes/No)

2.755 (1.064–3.325)

0.995

Surgical options

(Yes/No)

0.653 (0.473–0.901)

0.009

0.641 (0.461–0.910)

0.010

Drainage tube

(Yes/No)

0.523 (0.265–1.029)

0.061

Tumor location

(Descending/ Sigmoid/ Rectum)

2.407 (1.685–3.437)

< 0.001

2.542 (1.846–3.926)

< 0.001

Tumor diameter

(≥ 5/ < 5)

0.692 (0.504–0.951)

0.023

0.911 (0.652–1.273)

0.594

Tumor differentiation

(Poor/ Medium/ High)

4.887 (2.450–9.749)

< 0.001

3.546 (1.637–6.938)

< 0.001

TNM Stage

(I/II/III/IV)

0.705 (0.517–0.962)

0.028

0.836 (0.603–6.938)

0.283

CEA(ng/mL)

0.997 (0.989–1.005)

0.474

Leukocyte (10⁹/L)

1.020 (0.970–1.073)

0.430

Neutrophil (10⁹/L)

0.983 (0.924–1.045)

0.573

Platelet (10⁹/L)

1.001 (0.999–1.003)

0.291

Lymphocyte (10⁹/L)

1.082 (0.878–1.332)

0.457

Hemoglobin (g/L)

1.009 (1.001–1.016)

0.019

1.003 (0.603–6.938)

0.484

Albumin (g/dL)

1.037 (0.999–1.076)

0.053

NLR (10⁹/L)

(≥ 2.61/ < 2.61)

0.904 (0.318–1.130)

0.012

0.797 (0.564–1.124)

< 0.001

PLR (10⁹/L)

(≥ 204.04/ < 204.04)

1.202 (0.128–2.582)

0.009

1.980 (1.260–3.112)

0.003