Table 8 Univariate and multivariate COX regression analysis of DFS in patients with CAL

Age(years)

(≥ 60/ < 60)

0.071 (0.016–0.318)

0.001

5.500 (1.094–7.654)

0.039

BMI(kg/m²)

1.046 (0.936–1.170)

0.427

Hospitalization (day)

(≥ 25.5/ < 25.5)

2.683 (0.947–7.602)

0.063

Gender

(Male/Female)

2.752 (1.027–7.374)

0.044

1.061 (0.302–3.720)

0.927

Smoking

(Yes/No)

2.001 (1.873–6.158)

0.004

3.882 (0.517–7.052)

0.117

Alcohol

(Yes/No)

0.051 (0.007–0.388)

0.004

4.394 (1.288–10.991)

0.018

Diabetes

(Yes/No)

2.286 (1.294–6.092)

< 0.001

0.188 (0.054–0.661)

0.009

Hypertension

(Yes/No)

0.726 (0.300–1.756)

0.477

Cardiovascular disease

(Yes/No)

2.310 (0.645–8.273)

0.198

Abdominal operation

(Yes/No)

0.277 (0.017–4.628)

0.371

Intestinal polyps

(Yes/No)

0.065 (0.020–0.215)

< 0.001

0.004 (0.001–0.249)

0.011

Chemotherapy

(Yes/No)

1.375 (0.583–3.240)

0.467

Surgical options

(Yes/No)

1.256 (0.365–4.320)

0.717

Drainage tube

(Yes/No)

2.368 (0.207–7.145)

0.681

Tumor location

(Descending/ Sigmoid/ Rectum)

1.469 (0.832–2.594)

0.185

Tumor diameter

(≥ 5/ < 5)

1.611 (0.686–3.784)

0.274

Tumor differentiation

(Poor/ Medium/ High)

0.186 (0.053–0.654)

0.009

0.264 (0.073–0.956)

0.042

TNM Stage

(I/II/III/IV)

0.266 (0.086 -0.828)

0.022

4.467 (1.021 -9.541)

0.047

CEA(ng/mL)

0.994 (0.971–1.016)

0.576

Leukocyte (10⁹/L)

0.881 (0.730–1.063)

0.187

Neutrophil (10⁹/L)

0.809 (0.893–1.156)

0.921

Platelet (10⁹/L)

0.996 (0.991–1.001)

0.100

Lymphocyte (10⁹/L)

1.420 (0.681–2.958)

0.350

Hemoglobin (g/L)

0.995 (0.989–1.000)

0.060

Albumin (g/dL)

0.983 (0.885–1.091)

0.744

NLR(10⁹/L)

(≥ 2.61/ < 2.61)

0.232 (0.066–0.617)

0.023

9.282 (0.908–10.222)

0.031

PLR(10⁹/L)

(≥ 204.04/ < 204.04)

0.358 (0.148–0.762)

0.022

8.305 (1.079–9.862)

0.042